Complementary dynamic BH3 profiles predict co-operativity
between the multi-kinase inhibitor TG02 and the BH3 mimetic
ABT-199 in acute myeloid leukaemia cells

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Complementary dynamic BH3 profiles predict co-operativity between the multi-kinase inhibitor TG02 and the BH3 mimetic ABT-199 in acute myeloid leukaemia cells

Direct co-operation between sensitiser molecules BAD and NOXA in mediating apoptosis suggests that therapeutic agents which sensitise to BAD may complement agents which sensitise to NOXA. Dynamic BH3 profiling is a novel methodology that we have applied to the measurement of complementarity between...

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Bibliographic Details
Main Authors:	Pallis, Monica, Burrows, Francis, Ryan, Jeremy, Grundy, Martin, Seedhouse, Claire, Abdul-Aziz, Amina, Montero, Joan, Letai, Anthony, Russell, Nigel
Format:	Article
Published:	Impact Journals 2016
Subjects:	BAD NOXA TG02 ABT-199 AML
Online Access:	https://eprints.nottingham.ac.uk/43288/

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