Complementary dynamic BH3 profiles predict co-operativity between the multi-kinase inhibitor TG02 and the BH3 mimetic ABT-199 in acute myeloid leukaemia cells
Direct co-operation between sensitiser molecules BAD and NOXA in mediating apoptosis suggests that therapeutic agents which sensitise to BAD may complement agents which sensitise to NOXA. Dynamic BH3 profiling is a novel methodology that we have applied to the measurement of complementarity between...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Published: |
Impact Journals
2016
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| Subjects: | |
| Online Access: | https://eprints.nottingham.ac.uk/43288/ |