Novel selective β1-adrenoceptor antagonists for concomitant cardiovascular and respiratory disease

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Novel selective β1-adrenoceptor antagonists for concomitant cardiovascular and respiratory disease

β-Blockers reduce mortality and improve symptoms in people with heart disease. However, current clinically available β-blockers have poor selectivity for the cardiac β1-adrenoceptor (AR) over the lung β2-AR. Unwanted β2-blockade risks causing life-threatening bronchospasm and a reduction in the effi...

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Bibliographic Details
Main Authors:	Baker, Jillian G., Gardiner, Sheila M., Woolard, Jeanette, Fromont, Christophe, Jadhav, Gopal P., Mistry, Shailesh N., Thompson, Kevin S.J., Kellam, Barrie, Hill, Stephen J., Fischer, Peter M.
Format:	Article
Published:	Federation of American Society of Experimental Biology 2017
Subjects:	β-blocker Selectivity Heart disease Asthma
Online Access:	https://eprints.nottingham.ac.uk/41610/

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