Novel selective β1-adrenoceptor antagonists for concomitant cardiovascular and respiratory disease

Novel selective β1-adrenoceptor antagonists for concomitant cardiovascular and respiratory disease

β-Blockers reduce mortality and improve symptoms in people with heart disease. However, current clinically available β-blockers have poor selectivity for the cardiac β1-adrenoceptor (AR) over the lung β2-AR. Unwanted β2-blockade risks causing life-threatening bronchospasm and a reduction in the effi...

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Bibliographic Details
Main Authors: Baker, Jillian G., Gardiner, Sheila M., Woolard, Jeanette, Fromont, Christophe, Jadhav, Gopal P., Mistry, Shailesh N., Thompson, Kevin S.J., Kellam, Barrie, Hill, Stephen J., Fischer, Peter M.
Format: Article
Published: Federation of American Society of Experimental Biology 2017
Subjects:
β-blocker
Selectivity
Heart disease
Asthma
Online Access:https://eprints.nottingham.ac.uk/41610/

Internet

https://eprints.nottingham.ac.uk/41610/

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