Single-cell analysis: visualizing pharmaceutical and metabolite uptake in cells with label-free 3D mass spectrometry imaging

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Single-cell analysis: visualizing pharmaceutical and metabolite uptake in cells with label-free 3D mass spectrometry imaging

Detecting metabolites and parent compound within a cell type is now a priority for pharmaceutical development. In this context, three-dimensional secondary ion mass spectrometry (SIMS) imaging was used to investigate the cellular uptake of the antiarrhythmic agent amiodarone, a phospholipidosis-indu...

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Bibliographic Details
Main Authors:	Passarelli, Melissa K., Newman, Carla F., Marshall, Peter S., West, Andrew, Gilmore, Ian S., Bunch, Josephine, Alexander, Morgan R., Dollery, Colin T.
Format:	Article
Published:	American Chemical Society 2015
Online Access:	https://eprints.nottingham.ac.uk/37559/

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