Static and dynamic stress heterogeneity in a multiscale model of the asthmatic airway wall

QR Code

Static and dynamic stress heterogeneity in a multiscale model of the asthmatic airway wall

Airway hyperresponsiveness (AHR) is a key characteristic of asthma that remains poorly understood. Tidal breathing and deep inspiration ordinarily cause rapid relaxation of airway smooth muscle (ASM) (as demonstrated via application of length fluctuations to tissue strips) and are therefore implicat...

Full description

Bibliographic Details
Main Authors:	Hiorns, Jonathan E., Jensen, Oliver E., Brook, Bindi S.
Format:	Article
Published:	American Physiological Society 2016
Subjects:	airway hyperresponsiveness; circumferential stress; extracellular matrix; tidal breathing; deep inspirations
Online Access:	https://eprints.nottingham.ac.uk/37444/

Similar Items

Airway and parenchymal strains during bronchoconstriction in the precision cut lung slice
by: Hiorns, Jonathan E., et al.
Published: (2016)

An in vitro and in silico study of altered airway smooth muscle structure and function in a remodelled asthmatic airway
by: Brown, Sarah
Published: (2023)

MMP-1 activation contributes to airway smooth muscle growth and asthma severity
by: Naveed, Shams-un-nisa, et al.
Published: (2017)

Modelling cell–matrix interactions in airway smooth muscle cells
by: Irons, Linda
Published: (2019)

Mathematical modelling and imaging of asthmatic airways
by: Hiorns, Jonathan E.
Published: (2014)

The differential effects of azithromycin on the airway epithelium in vitro and in vivo
by: Slater, Mariel, et al.
Published: (2016)

Assessing the unified airway hypothesis in children via transcriptional profiling of the airway epithelium
by: Kicic, Anthony, et al.
Published: (2020)

A complex interplay between the extracellular matrix and the innate immune response to microbial pathogens
by: Tomlin, Hannah, et al.
Published: (2018)

Mathematical Models of Pro-remodelling Growth Factor Activation in Asthmatic Airways
by: Pybus, Hannah J.
Published: (2020)

Breath biomarkers of inflammation, infection and metabolic derangement in the intensive care unit
by: Sturney, Sharon C.
Published: (2015)

Matrix metalloproteinase-1 mediated extra-cellular matrix remodelling contributes to airway smooth muscle growth and asthma severity
by: Naveed, Shams-un-nisa
Published: (2018)

Dental stem cell delivery through new injectable matrices for spinal cord regeneration
by: Viswanath, Aiswarya
Published: (2018)

In vitro, in silico and in vivo study challenges the impact of bronchial thermoplasty on acute airway smooth muscle mass loss
by: Chernyavsky, Igor L., et al.
Published: (2018)

Restoring mucosal barrier function and modifying macrophage phenotype with an extracellular matrix hydrogel: potential therapy for ulcerative colitis
by: Keane, Timothy J., et al.
Published: (2017)

Liver progenitor cell interactions with the extracellular matrix
by: Zhu, C., et al.
Published: (2012)

Dysregulated repair in asthmatic paediatric airway epithelial cells: The role of plasminogen activator inhibitor-1
by: Stevens, P.T., et al.
Published: (2008)

ECM crosslinking enhances fibroblast growth and protects against matrix proteolysis in lung fibrosis
by: Philp, Christopher J., et al.
Published: (2017)

Engineering ‘extracellular matrix factories’ to study how the extracellular microenvironment regulates gene expression
by: Tomlin, Hannah
Published: (2021)

Regulation of ABCG2 through interactions with Alpha-1-Acid Glycoprotein and EMMPRIN
by: Likar, Sakura
Published: (2025)

Clonally expanded human airway smooth muscle cells exhibit morphological and functional heterogeneity
by: Singh, Shailendra R., et al.
Published: (2014)

Pharmacological ablation of the airway smooth muscle layer—Mathematical predictions of functional improvement in asthma
by: Donovan, G.M., et al.
Published: (2020)

The molecular and phenotypic basis of the glioma invasive perivascular niche
by: Diksin, Mohammed, et al.
Published: (2017)

Surface chemistry guidance in controllable neural stem cell differentiation to direct stem cell fate: future applications in building artificial neural networks
by: Dhowre, Hala Shakib
Published: (2018)

Tidal Effects on the Flow and Channel Geometry of Klang River Estuary
by: Mahdi, Muhannad A.
Published: (2000)

Investigating the role of tumour-deposited extracellular matrix in medulloblastoma progression
by: Johnson, James E. C.
Published: (2023)

The impact of detergents on the tissue decellularization process: a ToF-SIMS study
by: White, Lisa J., et al.
Published: (2017)

Macrophage phenotype in response to ECM bioscaffolds
by: Huleihel, Luai, et al.
Published: (2017)

A theoretical model of inflammation- and mechanotransduction- driven asthmatic airway remodelling
by: Hill, Michael, et al.
Published: (2018)

Nephronectin and the genetics of lung function variability
by: Qian, Guoqing
Published: (2023)

Airway remodeling blockade with an orally active geranyl acetophenone
by: Lee, Yu Zhao
Published: (2017)

PROFILING INTEGRIN EXPRESSION ON ASTHMATIC AND NON-ASTHMATIC AIRWAY EPITHELIAL CELLS
by: Iosifidis, T., et al.
Published: (2014)

Development of Crosslinked Bone Extracellular Matrix Hydrogels Using Naturally Derived Reagents
by: Jones, J.N.
Published: (2024)

Effects of Migrating Cell-Induced Matrix Reorganization on 3D Cancer Cell Migration
by: Sun, W., et al.
Published: (2014)

Developing platforms for tissue engineering of the airways
by: Ramis, Jopeth
Published: (2020)

A prebiotic galactooligosaccharide mixture reduces severity of hyperpnoea-induced bronchoconstriction and markers of airway inflammation
by: Williams, Neil C., et al.
Published: (2016)

An Evaluation of Change Management at British Airways: A Case Study
by: Khicha, Nidhi
Published: (2008)

Δ9-tetrahydrocannabinol reverses TNFα-induced increase in airway epithelial cell permeability through CB2 receptors
by: Shang, Valerie C.M., et al.
Published: (2016)

Fluid-structure interactions in the human upper airway — large-displacement biomechanics
by: Elliott, Novak, et al.
Published: (2010)

Development of biomimetic platforms to investigate the influence of the extra-cellular environment on immunological responses
by: Donaldson, Amy Rose
Published: (2017)

Customisable peptide hydrogels as user-defined biomimetic models of specific tissue microenvironments
by: Curd, Johnathan
Published: (2022)