Multiscale modelling of drug-polymer nanoparticle assembly identifies parameters influencing drug encapsulation efficiency

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Multiscale modelling of drug-polymer nanoparticle assembly identifies parameters influencing drug encapsulation efficiency

Using a multiscale (dual resolution) approach combining an atomistic (GROMOS96) and coarse-grain (MARTINI) force field, we have been able to simulate the process of drug-polymer nanoparticle assembly by nanoprecipitation from mixed solvents. Here we present the development and application of this me...

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Bibliographic Details
Main Authors:	Mackenzie, Robert, Booth, Jonathan, Alexander, Cameron, Garnett, Martin, Laughton, Charles A.
Format:	Article
Published:	American Chemical Society 2015
Subjects:	Nanoprecipitation Poly(glycerol adipate) Multiscale Modelling Drug Delivery
Online Access:	https://eprints.nottingham.ac.uk/29664/

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