Pre-clinical development of human apurinic/apyrimidinic endonuclease (APE1) inhibitors for cancer therapy

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Pre-clinical development of human apurinic/apyrimidinic endonuclease (APE1) inhibitors for cancer therapy

Modulation of DNA base excision repair (BER) has the potential to enhance response to chemotherapy and improve outcomes in tumours such as melanoma, glioma and pancreatic cancer. APE1, a critical protein in BER that processes potentially cytotoxic abasic sites (AP sites), is a promising new target i...

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Bibliographic Details
Main Author:	Mohammed, Mohammed Zubair Khuder
Format:	Thesis (University of Nottingham only)
Language:	English
Published:	2011
Subjects:	DNA repair DNA damage DNA base excision repair Cancer cell growth
Online Access:	https://eprints.nottingham.ac.uk/13980/

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