Pre-clinical development of human apurinic/apyrimidinic endonuclease (APE1) inhibitors for cancer therapy
Modulation of DNA base excision repair (BER) has the potential to enhance response to chemotherapy and improve outcomes in tumours such as melanoma, glioma and pancreatic cancer. APE1, a critical protein in BER that processes potentially cytotoxic abasic sites (AP sites), is a promising new target i...
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| Format: | Thesis (University of Nottingham only) |
| Language: | English |
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2011
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| Online Access: | https://eprints.nottingham.ac.uk/13980/ |