Effect of dietary n-6 to n-3 polyunsaturated fatty acid ratio on prostaglandin plasma levels and genes expression peroxisome proliferator-activated receptor (PPAR) in pregnant Sprague Dawley rats

The peroxisome proliferator-activated receptors (PPARs) are a family of nuclear transcription factors thought to act as receptors for polyunsaturated fatty acids and to reduce production of series 2 prostaglandins (PG). The objective of this study was to investigate the effect of different ratio n-6...

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Main Authors:	Ali, Amira Abdulbari, Abu Bakar @ Zakaria, Md Zuki, Goh, Yong Meng, Mohamed Mustapha, Noordin
Format:	Article
Language:	English
Published:	Academic Journals 2011
Online Access:	http://psasir.upm.edu.my/id/eprint/25333/ http://psasir.upm.edu.my/id/eprint/25333/ http://psasir.upm.edu.my/id/eprint/25333/1/25333.pdf

id	upm-25333
recordtype	eprints
spelling	upm-253332016-11-23T04:15:59Z http://psasir.upm.edu.my/id/eprint/25333/ Effect of dietary n-6 to n-3 polyunsaturated fatty acid ratio on prostaglandin plasma levels and genes expression peroxisome proliferator-activated receptor (PPAR) in pregnant Sprague Dawley rats Ali, Amira Abdulbari Abu Bakar @ Zakaria, Md Zuki Goh, Yong Meng Mohamed Mustapha, Noordin The peroxisome proliferator-activated receptors (PPARs) are a family of nuclear transcription factors thought to act as receptors for polyunsaturated fatty acids and to reduce production of series 2 prostaglandins (PG). The objective of this study was to investigate the effect of different ratio n-6: n-3 on the PPAR expression of rats endometrial tissue. The findings obtained from this study showed significant induction of PPARδ mRNA levels in endomatral cells treatment 1:1 group by 1.38 fold compared with the PPARδ mRNA levels in endomatral cells treatment 30:1 group. This induction was due to the cellular demands for prostaglandin were high in the endometrial cells when cells were treated with high ratio n6:n3 on 30:1 group, thus, resulting in an increase in both prostaglandin PGE2 and PGF2α production by induction of PPARδ genes. On the other hand, treatment 1:1 group and control group of endometrial cells did not show any significant changes in mRNA level of PPARδ, compared with treatment ratio n6:n3 on 6:1 group and treatment high ratio n6:n3 on 30:1 group of the endometrial cells. These findings show that inhibit ion of uterine PGF2α synthesis by n-3 fatty acids may depend on the amount of n-6 fatty acids reaching the target tissue. In conclusion, PPARδ function in the response of rat endometrium to long chain n-6:n3 polyunsaturated fatty acids. Academic Journals 2011-08-15 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/25333/1/25333.pdf Ali, Amira Abdulbari and Abu Bakar @ Zakaria, Md Zuki and Goh, Yong Meng and Mohamed Mustapha, Noordin (2011) Effect of dietary n-6 to n-3 polyunsaturated fatty acid ratio on prostaglandin plasma levels and genes expression peroxisome proliferator-activated receptor (PPAR) in pregnant Sprague Dawley rats. African Journal of Biotechnology, 10 (44). art. no. 2B2382729852. pp. 8703-8708. ISSN 1684–5315 http://www.academicjournals.org/journal/AJB/article-abstract/2B2382729852
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Putra Malaysia
building	UPM Institutional Repository
collection	Online Access
language	English
description	The peroxisome proliferator-activated receptors (PPARs) are a family of nuclear transcription factors thought to act as receptors for polyunsaturated fatty acids and to reduce production of series 2 prostaglandins (PG). The objective of this study was to investigate the effect of different ratio n-6: n-3 on the PPAR expression of rats endometrial tissue. The findings obtained from this study showed significant induction of PPARδ mRNA levels in endomatral cells treatment 1:1 group by 1.38 fold compared with the PPARδ mRNA levels in endomatral cells treatment 30:1 group. This induction was due to the cellular demands for prostaglandin were high in the endometrial cells when cells were treated with high ratio n6:n3 on 30:1 group, thus, resulting in an increase in both prostaglandin PGE2 and PGF2α production by induction of PPARδ genes. On the other hand, treatment 1:1 group and control group of endometrial cells did not show any significant changes in mRNA level of PPARδ, compared with treatment ratio n6:n3 on 6:1 group and treatment high ratio n6:n3 on 30:1 group of the endometrial cells. These findings show that inhibit ion of uterine PGF2α synthesis by n-3 fatty acids may depend on the amount of n-6 fatty acids reaching the target tissue. In conclusion, PPARδ function in the response of rat endometrium to long chain n-6:n3 polyunsaturated fatty acids.
format	Article
author	Ali, Amira Abdulbari Abu Bakar @ Zakaria, Md Zuki Goh, Yong Meng Mohamed Mustapha, Noordin
spellingShingle	Ali, Amira Abdulbari Abu Bakar @ Zakaria, Md Zuki Goh, Yong Meng Mohamed Mustapha, Noordin Effect of dietary n-6 to n-3 polyunsaturated fatty acid ratio on prostaglandin plasma levels and genes expression peroxisome proliferator-activated receptor (PPAR) in pregnant Sprague Dawley rats
author_facet	Ali, Amira Abdulbari Abu Bakar @ Zakaria, Md Zuki Goh, Yong Meng Mohamed Mustapha, Noordin
author_sort	Ali, Amira Abdulbari
title	Effect of dietary n-6 to n-3 polyunsaturated fatty acid ratio on prostaglandin plasma levels and genes expression peroxisome proliferator-activated receptor (PPAR) in pregnant Sprague Dawley rats
title_short	Effect of dietary n-6 to n-3 polyunsaturated fatty acid ratio on prostaglandin plasma levels and genes expression peroxisome proliferator-activated receptor (PPAR) in pregnant Sprague Dawley rats
title_full	Effect of dietary n-6 to n-3 polyunsaturated fatty acid ratio on prostaglandin plasma levels and genes expression peroxisome proliferator-activated receptor (PPAR) in pregnant Sprague Dawley rats
title_fullStr	Effect of dietary n-6 to n-3 polyunsaturated fatty acid ratio on prostaglandin plasma levels and genes expression peroxisome proliferator-activated receptor (PPAR) in pregnant Sprague Dawley rats
title_full_unstemmed	Effect of dietary n-6 to n-3 polyunsaturated fatty acid ratio on prostaglandin plasma levels and genes expression peroxisome proliferator-activated receptor (PPAR) in pregnant Sprague Dawley rats
title_sort	effect of dietary n-6 to n-3 polyunsaturated fatty acid ratio on prostaglandin plasma levels and genes expression peroxisome proliferator-activated receptor (ppar) in pregnant sprague dawley rats
publisher	Academic Journals
publishDate	2011
url	http://psasir.upm.edu.my/id/eprint/25333/ http://psasir.upm.edu.my/id/eprint/25333/ http://psasir.upm.edu.my/id/eprint/25333/1/25333.pdf
first_indexed	2018-09-07T14:56:38Z
last_indexed	2018-09-07T14:56:38Z
_version_	1610961072040181760

Effect of dietary n-6 to n-3 polyunsaturated fatty acid ratio on prostaglandin plasma levels and genes expression peroxisome proliferator-activated receptor (PPAR) in pregnant Sprague Dawley rats

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