Synthesis and Antibacterial Study of Aspirin-Chalcone Derivatives
The chemistry of aspirin and chalcone derivatives has been extensively studied and developed as one of the pharmaceutically important molecules. In this study, new aspirin-chalcone derivatives have been successfully synthesized and characterized via FTIR, 1H and 13C NMR spectroscopy. The antibacte...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Universiti Malaysia Sarawak, (UNIMAS)
2013
|
| Subjects: | |
| Online Access: | http://ir.unimas.my/15567/ http://ir.unimas.my/15567/ http://ir.unimas.my/15567/1/Synthesis%20and%20Antibacterial%20Study%20of%20Aspirin%20%28abstract%29.pdf |
| Summary: | The chemistry of aspirin and chalcone derivatives has been extensively studied and developed as one of the
pharmaceutically important molecules. In this study, new aspirin-chalcone derivatives have been successfully
synthesized and characterized via FTIR, 1H and 13C NMR spectroscopy. The antibacterial activities of
synthesized compounds were investigated towards Escherichia coli ATCC 8739 via turbidimetric kinetic
method. The newly synthesized aspirin-chalcone derivatives, however showed poor antibacterial activity
against E. coli ATCC 8739 at the concentration of 50, 80 and 100 ppm. The effect of the molecular structure
of the synthesized compounds on the antibacterial activity is discussed. |
|---|