Diverse Strategies Used by Picornaviruses to Escape Host RNA Decay Pathways

To successfully replicate, viruses protect their genomic material from degradation by the host cell. RNA viruses must contend with numerous destabilizing host cell processes including mRNA decay pathways and viral RNA (vRNA) degradation resulting from the antiviral response. Members of the Picornavi...

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Main Authors:	Ullmer, Wendy, Semler, Bert L.
Format:	Online
Language:	English
Published:	MDPI 2016
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5192396/

id	pubmed-5192396
recordtype	oai_dc
spelling	pubmed-51923962017-01-03 Diverse Strategies Used by Picornaviruses to Escape Host RNA Decay Pathways Ullmer, Wendy Semler, Bert L. Review To successfully replicate, viruses protect their genomic material from degradation by the host cell. RNA viruses must contend with numerous destabilizing host cell processes including mRNA decay pathways and viral RNA (vRNA) degradation resulting from the antiviral response. Members of the Picornaviridae family of small RNA viruses have evolved numerous diverse strategies to evade RNA decay, including incorporation of stabilizing elements into vRNA and re-purposing host stability factors. Viral proteins are deployed to disrupt and inhibit components of the decay machinery and to redirect decay machinery to the advantage of the virus. This review summarizes documented interactions of picornaviruses with cellular RNA decay pathways and processes. MDPI 2016-12-20 /pmc/articles/PMC5192396/ /pubmed/27999393 http://dx.doi.org/10.3390/v8120335 Text en © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Ullmer, Wendy Semler, Bert L.
spellingShingle	Ullmer, Wendy Semler, Bert L. Diverse Strategies Used by Picornaviruses to Escape Host RNA Decay Pathways
author_facet	Ullmer, Wendy Semler, Bert L.
author_sort	Ullmer, Wendy
title	Diverse Strategies Used by Picornaviruses to Escape Host RNA Decay Pathways
title_short	Diverse Strategies Used by Picornaviruses to Escape Host RNA Decay Pathways
title_full	Diverse Strategies Used by Picornaviruses to Escape Host RNA Decay Pathways
title_fullStr	Diverse Strategies Used by Picornaviruses to Escape Host RNA Decay Pathways
title_full_unstemmed	Diverse Strategies Used by Picornaviruses to Escape Host RNA Decay Pathways
title_sort	diverse strategies used by picornaviruses to escape host rna decay pathways
description	To successfully replicate, viruses protect their genomic material from degradation by the host cell. RNA viruses must contend with numerous destabilizing host cell processes including mRNA decay pathways and viral RNA (vRNA) degradation resulting from the antiviral response. Members of the Picornaviridae family of small RNA viruses have evolved numerous diverse strategies to evade RNA decay, including incorporation of stabilizing elements into vRNA and re-purposing host stability factors. Viral proteins are deployed to disrupt and inhibit components of the decay machinery and to redirect decay machinery to the advantage of the virus. This review summarizes documented interactions of picornaviruses with cellular RNA decay pathways and processes.
publisher	MDPI
publishDate	2016
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5192396/
_version_	1613833812599373824

Diverse Strategies Used by Picornaviruses to Escape Host RNA Decay Pathways

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