Interaction of cytokeratin 19 head domain and HER2 in the cytoplasm leads to activation of HER2-Erk pathway

Interaction of cytokeratin 19 head domain and HER2 in the cytoplasm leads to activation of HER2-Erk pathway

HER2 is a receptor tyrosine kinase and its upregulation via activating mutations or amplification has been identified in some malignant tumors, including lung cancers. Because HER2 can be a therapeutic target in HER2-driven malignancies, it is important to understand the molecular mechanisms of HER2...

Full description

Bibliographic Details
Main Authors: Ohtsuka, Tomoaki, Sakaguchi, Masakiyo, Yamamoto, Hiromasa, Tomida, Shuta, Takata, Katsuyoshi, Shien, Kazuhiko, Hashida, Shinsuke, Miyata-Takata, Tomoko, Watanabe, Mototsugu, Suzawa, Ken, Soh, Junichi, Youyi, Chen, Sato, Hiroki, Namba, Kei, Torigoe, Hidejiro, Tsukuda, Kazunori, Yoshino, Tadashi, Miyoshi, Shinichiro, Toyooka, Shinichi
Format: Online
Language:English
Published: Nature Publishing Group 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5180104/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5180104/

Similar Items