Functional TRAIL receptors in monocytes and tumor-associated macrophages: A possible targeting pathway in the tumor microenvironment

Functional TRAIL receptors in monocytes and tumor-associated macrophages: A possible targeting pathway in the tumor microenvironment

Despite the accepted dogma that TRAIL kills only tumor cells and spares normal ones, we show in this study that mononuclear phagocytes are susceptible to recombinant TRAIL via caspase-dependent apoptosis. Human resting monocytes and in vitro-differentiated macrophages expressed substantial levels of...

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Bibliographic Details
Main Authors: Liguori, Manuela, Buracchi, Chiara, Pasqualini, Fabio, Bergomas, Francesca, Pesce, Samantha, Sironi, Marina, Grizzi, Fabio, Mantovani, Alberto, Belgiovine, Cristina, Allavena, Paola
Format: Online
Language:English
Published: Impact Journals LLC 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5173086/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5173086/

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