Accurate de novo design of hyperstable constrained peptides
Naturally occurring, pharmacologically active peptides constrained with covalent crosslinks generally have shapes evolved to fit precisely into binding pockets on their targets. Such peptides can have excellent pharmaceutical properties, combining the stability and tissue penetration of small molecu...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Online |
| Language: | English |
| Published: |
2016
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5161715/ |