Expression of APOBEC3B mRNA in Primary Breast Cancer of Japanese Women

Recent studies have identified the apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 3B (APOBEC3B) as a source of mutations in various malignancies. APOBEC3B is overexpressed in several human cancer types, including breast cancer. In this study, we analyzed APOBEC3B mRNA expression in...

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Main Authors:	Tokunaga, Eriko, Yamashita, Nami, Tanaka, Kimihiro, Inoue, Yuka, Akiyoshi, Sayuri, Saeki, Hiroshi, Oki, Eiji, Kitao, Hiroyuki, Maehara, Yoshihiko
Format:	Online
Language:	English
Published:	Public Library of Science 2016
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5158016/

id	pubmed-5158016
recordtype	oai_dc
spelling	pubmed-51580162016-12-21 Expression of APOBEC3B mRNA in Primary Breast Cancer of Japanese Women Tokunaga, Eriko Yamashita, Nami Tanaka, Kimihiro Inoue, Yuka Akiyoshi, Sayuri Saeki, Hiroshi Oki, Eiji Kitao, Hiroyuki Maehara, Yoshihiko Research Article Recent studies have identified the apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 3B (APOBEC3B) as a source of mutations in various malignancies. APOBEC3B is overexpressed in several human cancer types, including breast cancer. In this study, we analyzed APOBEC3B mRNA expression in 305 primary breast cancers of Japanese women using quantitative reverse transcription-PCR, and investigated the relationships between the APOBEC3B mRNA expression and clinicopathological characteristics, prognosis, and TP53 mutations. The expression of APOBEC3B mRNA was detected in 277 tumors and not detected in 28 tumors. High APOBEC3B mRNA expression was significantly correlated with ER- and PR-negativity, high grade and high Ki67 index. The APOBEC3B mRNA expression was highest in the triple-negative and lowest in the hormone receptor-positive/HER2-negative subtypes. The TP53 gene was more frequently mutated in the tumors with high APOBEC3B mRNA expression. High APOBEC3B mRNA expression was significantly associated with poor recurrence-free survival in all cases and the ER-positive cases. These findings were almost consistent with the previous reports from the Western countries. In conclusion, high APOBEC3B mRNA expression was related to the aggressive phenotypes of breast cancer, high frequency of TP53 mutation and poor prognosis, especially in ER-positive tumors. Public Library of Science 2016-12-15 /pmc/articles/PMC5158016/ /pubmed/27977754 http://dx.doi.org/10.1371/journal.pone.0168090 Text en © 2016 Tokunaga et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Tokunaga, Eriko Yamashita, Nami Tanaka, Kimihiro Inoue, Yuka Akiyoshi, Sayuri Saeki, Hiroshi Oki, Eiji Kitao, Hiroyuki Maehara, Yoshihiko
spellingShingle	Tokunaga, Eriko Yamashita, Nami Tanaka, Kimihiro Inoue, Yuka Akiyoshi, Sayuri Saeki, Hiroshi Oki, Eiji Kitao, Hiroyuki Maehara, Yoshihiko Expression of APOBEC3B mRNA in Primary Breast Cancer of Japanese Women
author_facet	Tokunaga, Eriko Yamashita, Nami Tanaka, Kimihiro Inoue, Yuka Akiyoshi, Sayuri Saeki, Hiroshi Oki, Eiji Kitao, Hiroyuki Maehara, Yoshihiko
author_sort	Tokunaga, Eriko
title	Expression of APOBEC3B mRNA in Primary Breast Cancer of Japanese Women
title_short	Expression of APOBEC3B mRNA in Primary Breast Cancer of Japanese Women
title_full	Expression of APOBEC3B mRNA in Primary Breast Cancer of Japanese Women
title_fullStr	Expression of APOBEC3B mRNA in Primary Breast Cancer of Japanese Women
title_full_unstemmed	Expression of APOBEC3B mRNA in Primary Breast Cancer of Japanese Women
title_sort	expression of apobec3b mrna in primary breast cancer of japanese women
description	Recent studies have identified the apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 3B (APOBEC3B) as a source of mutations in various malignancies. APOBEC3B is overexpressed in several human cancer types, including breast cancer. In this study, we analyzed APOBEC3B mRNA expression in 305 primary breast cancers of Japanese women using quantitative reverse transcription-PCR, and investigated the relationships between the APOBEC3B mRNA expression and clinicopathological characteristics, prognosis, and TP53 mutations. The expression of APOBEC3B mRNA was detected in 277 tumors and not detected in 28 tumors. High APOBEC3B mRNA expression was significantly correlated with ER- and PR-negativity, high grade and high Ki67 index. The APOBEC3B mRNA expression was highest in the triple-negative and lowest in the hormone receptor-positive/HER2-negative subtypes. The TP53 gene was more frequently mutated in the tumors with high APOBEC3B mRNA expression. High APOBEC3B mRNA expression was significantly associated with poor recurrence-free survival in all cases and the ER-positive cases. These findings were almost consistent with the previous reports from the Western countries. In conclusion, high APOBEC3B mRNA expression was related to the aggressive phenotypes of breast cancer, high frequency of TP53 mutation and poor prognosis, especially in ER-positive tumors.
publisher	Public Library of Science
publishDate	2016
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5158016/
_version_	1613783039166382080

Expression of APOBEC3B mRNA in Primary Breast Cancer of Japanese Women

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