Questions and controversies: the role of necroptosis in liver disease
Acute and chronic liver injury results in hepatocyte death and turnover. If injury becomes chronic, the continuous cell death and turnover leads to chronic inflammation, fibrosis and ultimately cirrhosis and hepatocellular carcinoma. Controlling liver cell death both in acute injury, to rescue the l...
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Nature Publishing Group
2016
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5136616/ |
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pubmed-51366162016-12-06 Questions and controversies: the role of necroptosis in liver disease Dara, Lily Liu, Zhang-Xu Kaplowitz, Neil Review Article Acute and chronic liver injury results in hepatocyte death and turnover. If injury becomes chronic, the continuous cell death and turnover leads to chronic inflammation, fibrosis and ultimately cirrhosis and hepatocellular carcinoma. Controlling liver cell death both in acute injury, to rescue the liver from acute liver failure, and in chronic injury, to curb secondary inflammation and fibrosis, is of paramount importance as a therapeutic strategy. Both apoptosis and necrosis occur in the liver, but the occurrence of necroptosis in the liver and its contribution to liver disease is controversial. Necroptosis is a form of regulated necrosis which occurs in certain cell types when caspases (+/−cIAPs) are inhibited through the RIPK1-RIPK3 activation of MLKL. The occurrence of necroptosis in the liver has recently been examined in multiple liver injury models with conflicting results. The aim of this review is to summarize the published data with an emphasis on the controversies and remaining questions in the field. Nature Publishing Group 2016-12-05 /pmc/articles/PMC5136616/ /pubmed/27924226 http://dx.doi.org/10.1038/cddiscovery.2016.89 Text en Copyright © 2016 The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Dara, Lily Liu, Zhang-Xu Kaplowitz, Neil |
| spellingShingle |
Dara, Lily Liu, Zhang-Xu Kaplowitz, Neil Questions and controversies: the role of necroptosis in liver disease |
| author_facet |
Dara, Lily Liu, Zhang-Xu Kaplowitz, Neil |
| author_sort |
Dara, Lily |
| title |
Questions and controversies: the role of necroptosis in liver disease |
| title_short |
Questions and controversies: the role of necroptosis in liver disease |
| title_full |
Questions and controversies: the role of necroptosis in liver disease |
| title_fullStr |
Questions and controversies: the role of necroptosis in liver disease |
| title_full_unstemmed |
Questions and controversies: the role of necroptosis in liver disease |
| title_sort |
questions and controversies: the role of necroptosis in liver disease |
| description |
Acute and chronic liver injury results in hepatocyte death and turnover. If injury becomes chronic, the continuous cell death and turnover leads to chronic inflammation, fibrosis and ultimately cirrhosis and hepatocellular carcinoma. Controlling liver cell death both in acute injury, to rescue the liver from acute liver failure, and in chronic injury, to curb secondary inflammation and fibrosis, is of paramount importance as a therapeutic strategy. Both apoptosis and necrosis occur in the liver, but the occurrence of necroptosis in the liver and its contribution to liver disease is controversial. Necroptosis is a form of regulated necrosis which occurs in certain cell types when caspases (+/−cIAPs) are inhibited through the RIPK1-RIPK3 activation of MLKL. The occurrence of necroptosis in the liver has recently been examined in multiple liver injury models with conflicting results. The aim of this review is to summarize the published data with an emphasis on the controversies and remaining questions in the field. |
| publisher |
Nature Publishing Group |
| publishDate |
2016 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5136616/ |
| _version_ |
1613755895538253824 |