Control of the structural landscape and neuronal proteotoxicity of mutant Huntingtin by domains flanking the polyQ tract

Control of the structural landscape and neuronal proteotoxicity of mutant Huntingtin by domains flanking the polyQ tract

Many neurodegenerative diseases are linked to amyloid aggregation. In Huntington’s disease (HD), neurotoxicity correlates with an increased aggregation propensity of a polyglutamine (polyQ) expansion in exon 1 of mutant huntingtin protein (mHtt). Here we establish how the domains flanking the polyQ...

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Bibliographic Details
Main Authors: Shen, Koning, Calamini, Barbara, Fauerbach, Jonathan A, Ma, Boxue, Shahmoradian, Sarah H, Serrano Lachapel, Ivana L, Chiu, Wah, Lo, Donald C, Frydman, Judith
Format: Online
Language:English
Published: eLife Sciences Publications, Ltd 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5135392/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5135392/

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