Independent test assessment using the extreme value distribution theory

The new generation of whole genome sequencing platforms offers great possibilities and challenges for dissecting the genetic basis of complex traits. With a very high number of sequence variants, a naïve multiple hypothesis threshold correction hinders the identification of reliable associations by...

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Bibliographic Details
Main Authors: Almeida, Marcio, Blondell, Lucy, Peralta, Juan M., Kent, Jack W., Jun, Goo, Teslovich, Tanya M., Fuchsberger, Christian, Wood, Andrew R., Manning, Alisa K., Frayling, Timothy M., Cingolani, Pablo E., Sladek, Robert, Dyer, Thomas D., Abecasis, Goncalo, Duggirala, Ravindranath, Blangero, John
Format: Online
Language:English
Published: BioMed Central 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5133519/