Type I error rates of rare single nucleotide variants are inflated in tests of association with non–normally distributed traits using simple linear regression methods

Type I error rates of rare single nucleotide variants are inflated in tests of association with non–normally distributed traits using simple linear regression methods

In this study, the effects of (a) the minor allele frequency of the single nucleotide variant (SNV), (b) the degree of departure from normality of the trait, and (c) the position of the SNVs on type I error rates were investigated in the Genetic Analysis Workshop (GAW) 19 whole exome sequence data....

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Bibliographic Details
Main Authors: Schwantes-An, Tae-Hwi, Sung, Heejong, Sabourin, Jeremy A., Justice, Cristina M., Sorant, Alexa J. M., Wilson, Alexander F.
Format: Online
Language:English
Published: BioMed Central 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5133479/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5133479/

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