A Simple Bias Correction in Linear Regression for Quantitative Trait Association Under Two-Tail Extreme Selection
Selective genotyping can increase power in quantitative trait association. One example of selective genotyping is two-tail extreme selection, but simple linear regression analysis gives a biased genetic effect estimate. Here, we present a simple correction for the bias.
| Main Authors: | , , |
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| Format: | Online |
| Language: | English |
| Published: |
Springer US
2011
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3162965/ |