Astrocytes mediate neurovascular signaling to capillary pericytes but not to arterioles

Active neurons increase their energy supply by dilating nearby arterioles and capillaries. This neurovascular coupling underlies BOLD functional imaging signals, but its mechanism is controversial. Canonically, neurons release glutamate to activate metabotropic glutamate receptors (mGluR5) on astroc...

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Bibliographic Details
Main Authors: Mishra, Anusha, Reynolds, James P., Chen, Yang, Gourine, Alexander V., Rusakov, Dmitri A., Attwell, David
Format: Online
Language:English
Published: 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5131849/