Methylation of Breast Cancer Predisposition Genes in Early-Onset Breast Cancer: Australian Breast Cancer Family Registry

Methylation of Breast Cancer Predisposition Genes in Early-Onset Breast Cancer: Australian Breast Cancer Family Registry

DNA methylation can mimic the effects of both germline and somatic mutations for cancer predisposition genes such as BRCA1 and p16INK4a. Constitutional DNA methylation of the BRCA1 promoter has been well described and is associated with an increased risk of early-onset breast cancers that have BRCA1...

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Bibliographic Details
Main Authors: Scott, Cameron M., Joo, JiHoon Eric, O’Callaghan, Neil, Buchanan, Daniel D., Clendenning, Mark, Giles, Graham G., Hopper, John L., Wong, Ee Ming, Southey, Melissa C.
Format: Online
Language:English
Published: Public Library of Science 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5130174/

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