Modulating the Substrate Stiffness to Manipulate Differentiation of Resident Liver Stem Cells and to Improve the Differentiation State of Hepatocytes

In many cell types, several cellular processes, such as differentiation of stem/precursor cells, maintenance of differentiated phenotype, motility, adhesion, growth, and survival, strictly depend on the stiffness of extracellular matrix that, in vivo, characterizes their correspondent organ and tiss...

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Bibliographic Details
Main Authors: Cozzolino, Angela Maria, Noce, Valeria, Battistelli, Cecilia, Marchetti, Alessandra, Grassi, Germana, Cicchini, Carla, Tripodi, Marco, Amicone, Laura
Format: Online
Language:English
Published: Hindawi Publishing Corporation 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4737459/