Biocombinatorial Synthesis of Novel Lipopeptides by COM Domain-Mediated Reprogramming of the Plipastatin NRPS Complex

Biocombinatorial Synthesis of Novel Lipopeptides by COM Domain-Mediated Reprogramming of the Plipastatin NRPS Complex

Both donors and acceptors of communication-mediating (COM) domains are essential for coordinating intermolecular communication within nonribosomal peptides synthetases (NRPSs) complexes. Different sets of COM domains provide selectivity, allowing NRPSs to utilize different natural biosynthetic templ...

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Bibliographic Details
Main Authors: Liu, Hongxia, Gao, Ling, Han, Jinzhi, Ma, Zhi, Lu, Zhaoxin, Dai, Chen, Zhang, Chong, Bie, Xiaomei
Format: Online
Language:English
Published: Frontiers Media S.A. 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5112269/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5112269/

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