Module and individual domain deletions of NRPS to produce plipastatin derivatives in Bacillus subtilis

Module and individual domain deletions of NRPS to produce plipastatin derivatives in Bacillus subtilis

Abstract Background Plipastatin, an antifungal lipopeptide, is synthesized by a non-ribosomal peptide synthetase (NRPS) in Bacillus subtilis. However, little information is available on the combinatorial biosynthesis strategies applied in plipastatin biosynthetic pathway. In this study, we applied m...

Full description

Bibliographic Details
Main Authors: Ling Gao, Jianping Guo, Yun Fan, Zhi Ma, Zhaoxin Lu, Chong Zhang, Haizhen Zhao, Xiaomei Bie
Format: Article
Language:English
Published: BioMed Central 2018-05-01
Series:Microbial Cell Factories
Subjects:
Genetic engineering
Plipastatin synthetase
Novel lipopeptides
Module skipping
Online Access:http://link.springer.com/article/10.1186/s12934-018-0929-4

Internet

http://link.springer.com/article/10.1186/s12934-018-0929-4

Similar Items