Trabectedin Followed by Irinotecan Can Stabilize Disease in Advanced Translocation-Positive Sarcomas with Acceptable Toxicity

Trabectedin Followed by Irinotecan Can Stabilize Disease in Advanced Translocation-Positive Sarcomas with Acceptable Toxicity

Background. Preclinical data indicate that trabectedin followed by irinotecan has strong synergistic effects on Ewing sarcoma. This is presumably due to hypersensitization of the tumor cells to the camptothecin as an effect of trabectedin in addition to synergistic suppression of EWS-FLI1 downstrea...

Full description

Bibliographic Details
Main Authors: Herzog, J., von Klot-Heydenfeldt, F., Jabar, S., Ranft, A., Rossig, C., Dirksen, U., Van den Brande, J., D'Incalci, M., von Luettichau, I., Grohar, P. J., Berdel, W. E., Burdach, St.
Format: Online
Language:English
Published: Hindawi Publishing Corporation 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5098094/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5098094/

Similar Items