A chemical screen for medulloblastoma identifies quercetin as a putative radiosensitizer

Treatment of medulloblastoma in children fails in approximately 30% of patients, and is often accompanied by severe late sequelae. Therefore, more effective drugs are needed that spare normal tissue and diminish long-term side effects. Since radiotherapy plays a pivotal role in the treatment of medu...

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Main Authors:	Lagerweij, Tonny, Hiddingh, Lotte, Biesmans, Dennis, Crommentuijn, Matheus H.W., Cloos, Jacqueline, Li, Xiao-Nan, Kogiso, Mari, Tannous, Bakhos A., Vandertop, W. Peter, Noske, David P., Kaspers, Gertjan J.L., Würdinger, Tom, Hulleman, Esther
Format:	Online
Language:	English
Published:	Impact Journals LLC 2016
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5094961/

id	pubmed-5094961
recordtype	oai_dc
spelling	pubmed-50949612016-11-22 A chemical screen for medulloblastoma identifies quercetin as a putative radiosensitizer Lagerweij, Tonny Hiddingh, Lotte Biesmans, Dennis Crommentuijn, Matheus H.W. Cloos, Jacqueline Li, Xiao-Nan Kogiso, Mari Tannous, Bakhos A. Vandertop, W. Peter Noske, David P. Kaspers, Gertjan J.L. Würdinger, Tom Hulleman, Esther Research Paper Treatment of medulloblastoma in children fails in approximately 30% of patients, and is often accompanied by severe late sequelae. Therefore, more effective drugs are needed that spare normal tissue and diminish long-term side effects. Since radiotherapy plays a pivotal role in the treatment of medulloblastoma, we set out to identify novel drugs that could potentiate the effect of ionizing radiation. Impact Journals LLC 2016-03-08 /pmc/articles/PMC5094961/ /pubmed/26967057 http://dx.doi.org/10.18632/oncotarget.7980 Text en Copyright: © 2016 Lagerweij et al. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Lagerweij, Tonny Hiddingh, Lotte Biesmans, Dennis Crommentuijn, Matheus H.W. Cloos, Jacqueline Li, Xiao-Nan Kogiso, Mari Tannous, Bakhos A. Vandertop, W. Peter Noske, David P. Kaspers, Gertjan J.L. Würdinger, Tom Hulleman, Esther
spellingShingle	Lagerweij, Tonny Hiddingh, Lotte Biesmans, Dennis Crommentuijn, Matheus H.W. Cloos, Jacqueline Li, Xiao-Nan Kogiso, Mari Tannous, Bakhos A. Vandertop, W. Peter Noske, David P. Kaspers, Gertjan J.L. Würdinger, Tom Hulleman, Esther A chemical screen for medulloblastoma identifies quercetin as a putative radiosensitizer
author_facet	Lagerweij, Tonny Hiddingh, Lotte Biesmans, Dennis Crommentuijn, Matheus H.W. Cloos, Jacqueline Li, Xiao-Nan Kogiso, Mari Tannous, Bakhos A. Vandertop, W. Peter Noske, David P. Kaspers, Gertjan J.L. Würdinger, Tom Hulleman, Esther
author_sort	Lagerweij, Tonny
title	A chemical screen for medulloblastoma identifies quercetin as a putative radiosensitizer
title_short	A chemical screen for medulloblastoma identifies quercetin as a putative radiosensitizer
title_full	A chemical screen for medulloblastoma identifies quercetin as a putative radiosensitizer
title_fullStr	A chemical screen for medulloblastoma identifies quercetin as a putative radiosensitizer
title_full_unstemmed	A chemical screen for medulloblastoma identifies quercetin as a putative radiosensitizer
title_sort	chemical screen for medulloblastoma identifies quercetin as a putative radiosensitizer
description	Treatment of medulloblastoma in children fails in approximately 30% of patients, and is often accompanied by severe late sequelae. Therefore, more effective drugs are needed that spare normal tissue and diminish long-term side effects. Since radiotherapy plays a pivotal role in the treatment of medulloblastoma, we set out to identify novel drugs that could potentiate the effect of ionizing radiation.
publisher	Impact Journals LLC
publishDate	2016
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5094961/
_version_	1613712515338862592

A chemical screen for medulloblastoma identifies quercetin as a putative radiosensitizer

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