PARP inhibition sensitizes childhood high grade glioma, medulloblastoma and ependymoma to radiation

PARP inhibition sensitizes childhood high grade glioma, medulloblastoma and ependymoma to radiation

Poly ADP-ribose polymerase (PARP) is a protein involved in single strand break repair. Recently, PARP inhibitors have shown considerable promise in the treatment of several cancers, both in monotherapy and in combination with cytotoxic agents. Synthetic lethal action of PARP inhibitors has been obse...

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Bibliographic Details
Main Authors: van Vuurden, Dannis G., Hulleman, Esther, Meijer, Olga L.M., Wedekind, Laurine E., Kool, Marcel, Witt, Hendrik, Vandertop, Peter W. Peter, Würdinger, Thomas, Noske, David P., Kaspers, Gertjan J.L., Cloos, Jacqueline
Format: Online
Language:English
Published: Impact Journals LLC 2011
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3282104/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3282104/

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