The rate of meiotic gene conversion varies by sex and age

Meiotic recombination involves a combination of gene conversion and crossover events that along with mutations produce germline genetic diversity. Here, we report the discovery of 3,176 SNP and 61 indel gene conversions. Our estimate of the non-crossover (NCO) gene conversion rate (G) is 7.0 for SNP...

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Main Authors:	Halldorsson, Bjarni V., Hardarson, Marteinn T., Kehr, Birte, Styrkarsdottir, Unnur, Gylfason, Arnaldur, Thorleifsson, Gudmar, Zink, Florian, Jonasdottir, Adalbjorg, Jonasdottir, Aslaug, Sulem, Patrick, Masson, Gisli, Thorsteinsdottir, Unnur, Helgason, Agnar, Kong, Augustine, Gudbjartsson, Daniel F., Stefansson, Kari
Format:	Online
Language:	English
Published:	2016
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5083143/

id	pubmed-5083143
recordtype	oai_dc
spelling	pubmed-50831432017-03-19 The rate of meiotic gene conversion varies by sex and age Halldorsson, Bjarni V. Hardarson, Marteinn T. Kehr, Birte Styrkarsdottir, Unnur Gylfason, Arnaldur Thorleifsson, Gudmar Zink, Florian Jonasdottir, Adalbjorg Jonasdottir, Aslaug Sulem, Patrick Masson, Gisli Thorsteinsdottir, Unnur Helgason, Agnar Kong, Augustine Gudbjartsson, Daniel F. Stefansson, Kari Article Meiotic recombination involves a combination of gene conversion and crossover events that along with mutations produce germline genetic diversity. Here, we report the discovery of 3,176 SNP and 61 indel gene conversions. Our estimate of the non-crossover (NCO) gene conversion rate (G) is 7.0 for SNPs and 5.8 for indels per Mb per generation, and the GC bias is 67.6%. For indels we demonstrate a 65.6% preference for the shorter allele. NCO gene conversions from mothers are longer than those from fathers and G is 2.17 times greater in mothers. Notably, G increases with the age of mothers, but not fathers. A disproportionate number of NCO gene conversions in older mothers occur outside double strand break (DSB) regions and in regions with relatively low GC content. This points to age-related changes in the mechanisms of meiotic gene conversions in oocytes. 2016-09-19 2016-11 /pmc/articles/PMC5083143/ /pubmed/27643539 http://dx.doi.org/10.1038/ng.3669 Text en Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Halldorsson, Bjarni V. Hardarson, Marteinn T. Kehr, Birte Styrkarsdottir, Unnur Gylfason, Arnaldur Thorleifsson, Gudmar Zink, Florian Jonasdottir, Adalbjorg Jonasdottir, Aslaug Sulem, Patrick Masson, Gisli Thorsteinsdottir, Unnur Helgason, Agnar Kong, Augustine Gudbjartsson, Daniel F. Stefansson, Kari
spellingShingle	Halldorsson, Bjarni V. Hardarson, Marteinn T. Kehr, Birte Styrkarsdottir, Unnur Gylfason, Arnaldur Thorleifsson, Gudmar Zink, Florian Jonasdottir, Adalbjorg Jonasdottir, Aslaug Sulem, Patrick Masson, Gisli Thorsteinsdottir, Unnur Helgason, Agnar Kong, Augustine Gudbjartsson, Daniel F. Stefansson, Kari The rate of meiotic gene conversion varies by sex and age
author_facet	Halldorsson, Bjarni V. Hardarson, Marteinn T. Kehr, Birte Styrkarsdottir, Unnur Gylfason, Arnaldur Thorleifsson, Gudmar Zink, Florian Jonasdottir, Adalbjorg Jonasdottir, Aslaug Sulem, Patrick Masson, Gisli Thorsteinsdottir, Unnur Helgason, Agnar Kong, Augustine Gudbjartsson, Daniel F. Stefansson, Kari
author_sort	Halldorsson, Bjarni V.
title	The rate of meiotic gene conversion varies by sex and age
title_short	The rate of meiotic gene conversion varies by sex and age
title_full	The rate of meiotic gene conversion varies by sex and age
title_fullStr	The rate of meiotic gene conversion varies by sex and age
title_full_unstemmed	The rate of meiotic gene conversion varies by sex and age
title_sort	rate of meiotic gene conversion varies by sex and age
description	Meiotic recombination involves a combination of gene conversion and crossover events that along with mutations produce germline genetic diversity. Here, we report the discovery of 3,176 SNP and 61 indel gene conversions. Our estimate of the non-crossover (NCO) gene conversion rate (G) is 7.0 for SNPs and 5.8 for indels per Mb per generation, and the GC bias is 67.6%. For indels we demonstrate a 65.6% preference for the shorter allele. NCO gene conversions from mothers are longer than those from fathers and G is 2.17 times greater in mothers. Notably, G increases with the age of mothers, but not fathers. A disproportionate number of NCO gene conversions in older mothers occur outside double strand break (DSB) regions and in regions with relatively low GC content. This points to age-related changes in the mechanisms of meiotic gene conversions in oocytes.
publishDate	2016
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5083143/
_version_	1613700952757370880

The rate of meiotic gene conversion varies by sex and age

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