Targeting of glioblastoma cell lines and glioma stem cells by combined PIM kinase and PI3K-p110α inhibition

Targeting of glioblastoma cell lines and glioma stem cells by combined PIM kinase and PI3K-p110α inhibition

The PIM family of proteins encodes serine/threonine kinases with important roles in protein synthesis and cancer cell metabolism. In glioblastoma (GBM) cell lines, siRNA-mediated knockdown of PIM kinases or pharmacological inhibition of PIM kinases by SGI-1776 or AZD-1208 results in reduced phosphor...

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Bibliographic Details
Main Authors: Iqbal, Asneha, Eckerdt, Frank, Bell, Jonathan, Nakano, Ichiro, Giles, Francis J., Cheng, Shi-Yuan, Lulla, Rishi R., Goldman, Stewart, Platanias, Leonidas C.
Format: Online
Language:English
Published: Impact Journals LLC 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5078085/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5078085/

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