Mechanism of TRIM25 Catalytic Activation in the Antiviral RIG-I Pathway

Mechanism of TRIM25 Catalytic Activation in the Antiviral RIG-I Pathway

Antiviral response pathways induce interferon by higher-order assembly of signaling complexes called signalosomes. Assembly of the RIG-I signalosome is regulated by K63-linked polyubiquitin chains, which are synthesized by the E3 ubiquitin ligase, TRIM25. We have previously shown that the TRIM25 coi...

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Bibliographic Details
Main Authors: Sanchez, Jacint G., Chiang, Jessica J., Sparrer, Konstantin M.J., Alam, Steven L., Chi, Michael, Roganowicz, Marcin D., Sankaran, Banumathi, Gack, Michaela U., Pornillos, Owen
Format: Online
Language:English
Published: 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5076470/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5076470/

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