Mechanism of B-box 2 domain-mediated higher-order assembly of the retroviral restriction factor TRIM5α

Mechanism of B-box 2 domain-mediated higher-order assembly of the retroviral restriction factor TRIM5α

Restriction factors and pattern recognition receptors are important components of intrinsic cellular defenses against viral infection. Mammalian TRIM5α proteins are restriction factors and receptors that target the capsid cores of retroviruses and activate ubiquitin-dependent antiviral responses upo...

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Bibliographic Details
Main Authors: Wagner, Jonathan M, Roganowicz, Marcin D, Skorupka, Katarzyna, Alam, Steven L, Christensen, Devin, Doss, Ginna, Wan, Yueping, Frank, Gabriel A, Ganser-Pornillos, Barbie K, Sundquist, Wesley I, Pornillos, Owen
Format: Online
Language:English
Published: eLife Sciences Publications, Ltd 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4936894/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4936894/

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