MiR-146 and miR-125 in the regulation of innate immunity and inflammation
Innate immune responses are primary, relatively limited, and specific responses to numerous pathogens and toxic molecules. Protein expression involved in these innate responses must be tightly regulated at both transcriptional level and post-transcriptional level to avoid the development of excessiv...
| Main Authors: | , , |
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| Format: | Online |
| Language: | English |
| Published: |
Korean Society for Biochemistry and Molecular
Biology
2016
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5070718/ |
| Summary: | Innate immune responses are primary, relatively limited, and specific responses
to numerous pathogens and toxic molecules. Protein expression involved in these
innate responses must be tightly regulated at both transcriptional level and
post-transcriptional level to avoid the development of excessive inflammation
that can be potentially harmful to the host. MicroRNAs are small noncoding RNAs
(∼22 nucleotides [nts]) that participate in the regulation of numerous
physiological responses by targeting specific messenger RNAs to suppress their
translation. Recent work has shown that several negative regulators of
transcription including microRNAs play important roles in inhibiting the
exacerbation of inflammatory responses and in the maintenance of immunological
homeostasis. This emerging research area will provide new insights on how
microRNAs regulate innate immune signaling. It might show that dysregulation of
microRNA synthesis is associated with the pathogenesis of inflammatory and
infectious diseases. In this review, we focused on miR-146 and miR-125 and
described the roles these miRNAs in modulating innate immune signaling. These
microRNAs can control inflammatory responses and the outcomes of pathogenic
infections. [BMB Reports 2016; 49(6): 311-318] |
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