Nitrotriazole-based acetamides and propanamides with broad spectrum antitrypanosomal activity

3-Nitro-1H-1,2,4-triazole-based acetamides bearing a biphenyl- or a phenoxyphenyl moiety have shown remarkable antichagasic activity both in vitro and in an acute murine model, as well as substantial in vitro antileishmanial activity but lacked activity against human African trypanosomiasis. We have...

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Bibliographic Details
Main Authors: Papadopoulou, Maria V., Bloomer, William D., Rosenzweig, Howard S., Wilkinson, Shane R., Szular, Joanna, Kaiser, Marcel
Format: Online
Language:English
Published: Editions Scientifiques Elsevier 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5049494/