The DNA cytosine deaminase APOBEC3H haplotype I likely contributes to breast and lung cancer mutagenesis

The DNA cytosine deaminase APOBEC3H haplotype I likely contributes to breast and lung cancer mutagenesis

Cytosine mutations within TCA/T motifs are common in cancer. A likely cause is the DNA cytosine deaminase APOBEC3B (A3B). However, A3B-null breast tumours still have this mutational bias. Here we show that APOBEC3H haplotype I (A3H-I) provides a likely solution to this paradox. A3B-null tumours with...

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Bibliographic Details
Main Authors: Starrett, Gabriel J., Luengas, Elizabeth M., McCann, Jennifer L., Ebrahimi, Diako, Temiz, Nuri A., Love, Robin P., Feng, Yuqing, Adolph, Madison B., Chelico, Linda, Law, Emily K., Carpenter, Michael A., Harris, Reuben S
Format: Online
Language:English
Published: Nature Publishing Group 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5036005/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5036005/

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