Defects in muscle branched-chain amino acid oxidation contribute to impaired lipid metabolism

Defects in muscle branched-chain amino acid oxidation contribute to impaired lipid metabolism

•Human insulin resistance is associated with perturbed muscle BCAA metabolism.•Experimental modulation of BCAA metabolic flux alters fatty acid oxidation in vitro.•Mut heterozygosis leads to increased body weigh and muscle TAG accumulation in mice.

Bibliographic Details
Main Authors: Lerin, Carles, Goldfine, Allison B., Boes, Tanner, Liu, Manway, Kasif, Simon, Dreyfuss, Jonathan M., De Sousa-Coelho, Ana Luisa, Daher, Grace, Manoli, Irini, Sysol, Justin R., Isganaitis, Elvira, Jessen, Niels, Goodyear, Laurie J., Beebe, Kirk, Gall, Walt, Venditti, Charles P., Patti, Mary-Elizabeth
Format: Online
Language:English
Published: Elsevier 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5034611/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5034611/

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