CD301b+ dendritic cells suppress T follicular helper cells and antibody responses to protein antigens

Strong antibody response is considered a hallmark of a successful vaccine. While dendritic cells (DCs) are important for T follicular helper (Tfh) cell priming, how this process is regulated in vivo is unclear. We show here that the depletion of CD301b+ DCs specifically enhanced the development of T...

Full description

Bibliographic Details
Main Authors: Kumamoto, Yosuke, Hirai, Toshiro, Wong, Patrick W, Kaplan, Daniel H, Iwasaki, Akiko
Format: Online
Language:English
Published: eLife Sciences Publications, Ltd 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5033605/