SPATA2 Links CYLD to LUBAC, Activates CYLD, and Controls LUBAC Signaling

SPATA2 Links CYLD to LUBAC, Activates CYLD, and Controls LUBAC Signaling

The linear ubiquitin chain assembly complex (LUBAC) regulates immune signaling, and its function is regulated by the deubiquitinases OTULIN and CYLD, which associate with the catalytic subunit HOIP. However, the mechanism through which CYLD interacts with HOIP is unclear. We here show that CYLD inte...

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Bibliographic Details
Main Authors: Elliott, Paul R., Leske, Derek, Hrdinka, Matous, Bagola, Katrin, Fiil, Berthe K., McLaughlin, Stephen H., Wagstaff, Jane, Volkmar, Norbert, Christianson, John C., Kessler, Benedikt M., Freund, Stefan M.V., Komander, David, Gyrd-Hansen, Mads
Format: Online
Language:English
Published: Cell Press 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5031558/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5031558/

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