G-CSF maintains controlled neutrophil mobilization during acute inflammation by negatively regulating CXCR2 signaling

G-CSF maintains controlled neutrophil mobilization during acute inflammation by negatively regulating CXCR2 signaling

Luo et al. report that CXCR2 ligands are responsible for rapid neutrophil mobilization during early-stage acute inflammation and that G-CSF suppresses this mobilization by negatively regulating CXCR2-mediated intracellular signaling.

Bibliographic Details
Main Authors: Bajrami, Besnik, Zhu, Haiyan, Kwak, Hyun-Jeong, Mondal, Subhanjan, Hou, Qingming, Geng, Guangfeng, Karatepe, Kutay, Zhang, Yu C., Nombela-Arrieta, César, Park, Shin-Young, Loison, Fabien, Sakai, Jiro, Xu, Yuanfu, Silberstein, Leslie E., Luo, Hongbo R.
Format: Online
Language:English
Published: The Rockefeller University Press 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5030805/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5030805/

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