The DEK oncogene activates VEGF expression and promotes tumor angiogenesis and growth in HIF-1α-dependent and -independent manners

The DEK oncogene activates VEGF expression and promotes tumor angiogenesis and growth in HIF-1α-dependent and -independent manners

The DEK oncogene is overexpressed in various cancers and overexpression of DEK correlates with poor clinical outcome. Vascular endothelial growth factor (VEGF) is the most important regulator of tumor angiogenesis, a process essential for tumor growth and metastasis. However, whether DEK enhances tu...

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Bibliographic Details
Main Authors: Zhang, Yanan, Liu, Jie, Wang, Shibin, Luo, Xiaoli, Li, Yang, Lv, Zhaohui, Zhu, Jie, Lin, Jing, Ding, Lihua, Ye, Qinong
Format: Online
Language:English
Published: Impact Journals LLC 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5029660/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5029660/

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