The human DEK oncogene regulates DNA damage response signaling and repair

The human DEK oncogene regulates DNA damage response signaling and repair

The human DEK gene is frequently overexpressed and sometimes amplified in human cancer. Consistent with oncogenic functions, Dek knockout mice are partially resistant to chemically induced papilloma formation. Additionally, DEK knockdown in vitro sensitizes cancer cells to DNA damaging agents and in...

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Bibliographic Details
Main Authors: Kavanaugh, Gina M., Wise-Draper, Trisha M., Morreale, Richard J., Morrison, Monique A., Gole, Boris, Schwemberger, Sandy, Tichy, Elisia D., Lu, Lu, Babcock, George F., Wells, James M., Drissi, Rachid, Bissler, John J., Stambrook, Peter J., Andreassen, Paul R., Wiesmüller, Lisa, Wells, Susanne I.
Format: Online
Language:English
Published: Oxford University Press 2011
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3177200/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3177200/

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