Effect of sorafenib on cisplatin-based chemoradiation in head and neck cancer cells

Despite aggressive chemoradiation (CRT) protocols in the treatment of patients with head and neck squamous cell carcinomas (HNSCC), the outcome is still unfavorable. To improve therapy efficacy we had already successfully tested the multikinase inhibitor sorafenib in combination with irradiation (IR...

Full description

Bibliographic Details
Main Authors:	Möckelmann, Nikolaus, Rieckmann, Thorsten, Busch, Chia-Jung, Becker, Benjamin, Gleißner, Lisa, Hoffer, Konstantin, Omniczynski, Maria, Steinmeister, Leonhard, Laban, Simon, Grénman, Reidar, Petersen, Cordula, Rothkamm, Kai, Dikomey, Ekkehard, Knecht, Rainald, Kriegs, Malte
Format:	Online
Language:	English
Published:	Impact Journals LLC 2016
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5029646/

id	pubmed-5029646
recordtype	oai_dc
spelling	pubmed-50296462016-09-29 Effect of sorafenib on cisplatin-based chemoradiation in head and neck cancer cells Möckelmann, Nikolaus Rieckmann, Thorsten Busch, Chia-Jung Becker, Benjamin Gleißner, Lisa Hoffer, Konstantin Omniczynski, Maria Steinmeister, Leonhard Laban, Simon Grénman, Reidar Petersen, Cordula Rothkamm, Kai Dikomey, Ekkehard Knecht, Rainald Kriegs, Malte Research Paper Despite aggressive chemoradiation (CRT) protocols in the treatment of patients with head and neck squamous cell carcinomas (HNSCC), the outcome is still unfavorable. To improve therapy efficacy we had already successfully tested the multikinase inhibitor sorafenib in combination with irradiation (IR) in previous studies on HNSCC cell lines. In this study we investigated its effect on combined CRT treatment using cisplatin.Radio- and chemosensitivity with and without sorafenib was measured in four HNSCC cell lines and normal fibroblasts (NF) by colony formation assay. Apoptosis and cell cycle analysis were performed by flow cytometry. Impact Journals LLC 2016-03-22 /pmc/articles/PMC5029646/ /pubmed/27015558 http://dx.doi.org/10.18632/oncotarget.8275 Text en Copyright: © 2016 Möckelmann et al. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Möckelmann, Nikolaus Rieckmann, Thorsten Busch, Chia-Jung Becker, Benjamin Gleißner, Lisa Hoffer, Konstantin Omniczynski, Maria Steinmeister, Leonhard Laban, Simon Grénman, Reidar Petersen, Cordula Rothkamm, Kai Dikomey, Ekkehard Knecht, Rainald Kriegs, Malte
spellingShingle	Möckelmann, Nikolaus Rieckmann, Thorsten Busch, Chia-Jung Becker, Benjamin Gleißner, Lisa Hoffer, Konstantin Omniczynski, Maria Steinmeister, Leonhard Laban, Simon Grénman, Reidar Petersen, Cordula Rothkamm, Kai Dikomey, Ekkehard Knecht, Rainald Kriegs, Malte Effect of sorafenib on cisplatin-based chemoradiation in head and neck cancer cells
author_facet	Möckelmann, Nikolaus Rieckmann, Thorsten Busch, Chia-Jung Becker, Benjamin Gleißner, Lisa Hoffer, Konstantin Omniczynski, Maria Steinmeister, Leonhard Laban, Simon Grénman, Reidar Petersen, Cordula Rothkamm, Kai Dikomey, Ekkehard Knecht, Rainald Kriegs, Malte
author_sort	Möckelmann, Nikolaus
title	Effect of sorafenib on cisplatin-based chemoradiation in head and neck cancer cells
title_short	Effect of sorafenib on cisplatin-based chemoradiation in head and neck cancer cells
title_full	Effect of sorafenib on cisplatin-based chemoradiation in head and neck cancer cells
title_fullStr	Effect of sorafenib on cisplatin-based chemoradiation in head and neck cancer cells
title_full_unstemmed	Effect of sorafenib on cisplatin-based chemoradiation in head and neck cancer cells
title_sort	effect of sorafenib on cisplatin-based chemoradiation in head and neck cancer cells
description	Despite aggressive chemoradiation (CRT) protocols in the treatment of patients with head and neck squamous cell carcinomas (HNSCC), the outcome is still unfavorable. To improve therapy efficacy we had already successfully tested the multikinase inhibitor sorafenib in combination with irradiation (IR) in previous studies on HNSCC cell lines. In this study we investigated its effect on combined CRT treatment using cisplatin.Radio- and chemosensitivity with and without sorafenib was measured in four HNSCC cell lines and normal fibroblasts (NF) by colony formation assay. Apoptosis and cell cycle analysis were performed by flow cytometry.
publisher	Impact Journals LLC
publishDate	2016
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5029646/
_version_	1613655955369623552

Effect of sorafenib on cisplatin-based chemoradiation in head and neck cancer cells

Similar Items