Palladium‐Catalyzed Oxidative Synthesis of α‐Acetoxylated Enones from Alkynes
We report a palladium‐catalyzed oxidative functionalization of alkynes to generate α‐acetoxylated enones in one step. A range of functional groups are well‐tolerated in this reaction. Mechanistic studies, including the use of 18O‐labeled DMSO, revealed that the ketone oxygen atom in the product orig...
| Main Authors: | , , , , |
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| Format: | Online |
| Language: | English |
| Published: |
John Wiley and Sons Inc.
2016
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5021131/ |
| Summary: | We report a palladium‐catalyzed oxidative functionalization of alkynes to generate α‐acetoxylated enones in one step. A range of functional groups are well‐tolerated in this reaction. Mechanistic studies, including the use of 18O‐labeled DMSO, revealed that the ketone oxygen atom in the product originates from DMSO. |
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