The Structural Architecture of an Infectious Mammalian Prion Using Electron Cryomicroscopy

The Structural Architecture of an Infectious Mammalian Prion Using Electron Cryomicroscopy

The structure of the infectious prion protein (PrPSc), which is responsible for Creutzfeldt-Jakob disease in humans and bovine spongiform encephalopathy, has escaped all attempts at elucidation due to its insolubility and propensity to aggregate. PrPSc replicates by converting the non-infectious, ce...

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Bibliographic Details
Main Authors: Vázquez-Fernández, Ester, Vos, Matthijn R., Afanasyev, Pavel, Cebey, Lino, Sevillano, Alejandro M., Vidal, Enric, Rosa, Isaac, Renault, Ludovic, Ramos, Adriana, Peters, Peter J., Fernández, José Jesús, van Heel, Marin, Young, Howard S., Requena, Jesús R., Wille, Holger
Format: Online
Language:English
Published: Public Library of Science 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5015997/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5015997/

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