Covalent ISG15 conjugation positively regulates the ubiquitin E3 ligase activity of parkin
Parkinson's disease (PD) is characterized by selective loss of dopaminergic neurons in the pars compacta of the substantia nigra and accumulation of ubiquitinated proteins in aggregates called Lewy bodies. Several mutated genes have been found in familial PD patients, including SNCA (α-synuclei...
| Main Authors: | , , , , |
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| Format: | Online |
| Language: | English |
| Published: |
The Royal Society
2016
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5008018/ |