Nucleophosmin: from structure and function to disease development

Nucleophosmin (NPM1) is a critical cellular protein that has been implicated in a number of pathways including mRNA transport, chromatin remodeling, apoptosis and genome stability. NPM1 function is a critical requirement for normal cellular biology as is underlined in cancer where NPM1 is commonly o...

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Main Authors:	Box, Joseph K., Paquet, Nicolas, Adams, Mark N., Boucher, Didier, Bolderson, Emma, O’Byrne, Kenneth J., Richard, Derek J.
Format:	Online
Language:	English
Published:	BioMed Central 2016
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4995807/

id	pubmed-4995807
recordtype	oai_dc
spelling	pubmed-49958072016-08-25 Nucleophosmin: from structure and function to disease development Box, Joseph K. Paquet, Nicolas Adams, Mark N. Boucher, Didier Bolderson, Emma O’Byrne, Kenneth J. Richard, Derek J. Review Nucleophosmin (NPM1) is a critical cellular protein that has been implicated in a number of pathways including mRNA transport, chromatin remodeling, apoptosis and genome stability. NPM1 function is a critical requirement for normal cellular biology as is underlined in cancer where NPM1 is commonly overexpressed, mutated, rearranged and sporadically deleted. Consistent with a multifunctional role within the cell, NPM1 can function not only as a proto-oncogene but also as a tumor suppressor. The aim of this review is to look at the less well-described role of NPM1 in the DNA repair pathways as well as the role of NPM1 in the regulation of apoptosis and its mutation in cancers. BioMed Central 2016-08-24 /pmc/articles/PMC4995807/ /pubmed/27553022 http://dx.doi.org/10.1186/s12867-016-0073-9 Text en © The Author(s) 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Box, Joseph K. Paquet, Nicolas Adams, Mark N. Boucher, Didier Bolderson, Emma O’Byrne, Kenneth J. Richard, Derek J.
spellingShingle	Box, Joseph K. Paquet, Nicolas Adams, Mark N. Boucher, Didier Bolderson, Emma O’Byrne, Kenneth J. Richard, Derek J. Nucleophosmin: from structure and function to disease development
author_facet	Box, Joseph K. Paquet, Nicolas Adams, Mark N. Boucher, Didier Bolderson, Emma O’Byrne, Kenneth J. Richard, Derek J.
author_sort	Box, Joseph K.
title	Nucleophosmin: from structure and function to disease development
title_short	Nucleophosmin: from structure and function to disease development
title_full	Nucleophosmin: from structure and function to disease development
title_fullStr	Nucleophosmin: from structure and function to disease development
title_full_unstemmed	Nucleophosmin: from structure and function to disease development
title_sort	nucleophosmin: from structure and function to disease development
description	Nucleophosmin (NPM1) is a critical cellular protein that has been implicated in a number of pathways including mRNA transport, chromatin remodeling, apoptosis and genome stability. NPM1 function is a critical requirement for normal cellular biology as is underlined in cancer where NPM1 is commonly overexpressed, mutated, rearranged and sporadically deleted. Consistent with a multifunctional role within the cell, NPM1 can function not only as a proto-oncogene but also as a tumor suppressor. The aim of this review is to look at the less well-described role of NPM1 in the DNA repair pathways as well as the role of NPM1 in the regulation of apoptosis and its mutation in cancers.
publisher	BioMed Central
publishDate	2016
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4995807/
_version_	1613633635451142144

Nucleophosmin: from structure and function to disease development

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