RNA methyltransferase NSUN2 promotes stress-induced HUVEC senescence

RNA methyltransferase NSUN2 promotes stress-induced HUVEC senescence

The tRNA methyltransferase NSUN2 delays replicative senescence by regulating the translation of CDK1 and CDKN1B mRNAs. However, whether NSUN2 influences premature cellular senescence remains untested. Here we show that NSUN2 methylates SHC mRNA in vitro and in cells, thereby enhancing the translatio...

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Bibliographic Details
Main Authors: Cai, Xiaoyu, Hu, Yuanyuan, Tang, Hao, Hu, Han, Pang, Lijun, Xing, Junyue, Liu, Zhenyun, Luo, Yuhong, Jiang, Bin, Liu, Te, Gorospe, Myriam, Chen, Chuan, Wang, Wengong
Format: Online
Language:English
Published: Impact Journals LLC 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4991368/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4991368/

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