Globin mRNA reduction for whole-blood transcriptome sequencing

Globin mRNA reduction for whole-blood transcriptome sequencing

The transcriptome analysis of whole-blood RNA by sequencing holds promise for the identification and tracking of biomarkers; however, the high globin mRNA (gmRNA) content of erythrocytes hampers whole-blood and buffy coat analyses. We introduce a novel gmRNA locking assay (GlobinLock, GL) as a robus...

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Main Authors: Krjutškov, Kaarel, Koel, Mariann, Roost, Anne Mari, Katayama, Shintaro, Einarsdottir, Elisabet, Jouhilahti, Eeva-Mari, Söderhäll, Cilla, Jaakma, Ülle, Plaas, Mario, Vesterlund, Liselotte, Lohi, Hannes, Salumets, Andres, Kere, Juha
Format: Online
Language:English
Published: Nature Publishing Group 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4981843/

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