Rescuing neuronal cell death by RAIDD- and PIDD- derived peptides and its implications for therapeutic intervention in neurodegenerative diseases

Caspase-2 is known to be involved in oxidative-stress mediated neuronal cell death. In this study, we demonstrated that rotenone-induced neuronal cell death is mediated by caspase-2 activation via PIDDosome formation. Our newly designed TAT-fused peptides, which contains wild-type helix number3 (H3)...

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Bibliographic Details
Main Authors: Jang, Tae-Ho, Lim, In-Hye, Kim, Chang Min, Choi, Jae Young, Kim, Eun-Ae, Lee, Tae-Jin, Park, Hyun Ho
Format: Online
Language:English
Published: Nature Publishing Group 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4977500/